Article
Kisspeptins in human reproduction-future therapeutic potential.
Journal of assisted reproduction and genetics - 1 Oct 2012
Kaur Kulvinder Kochar, Allahbadia Gautam, Singh Mandeep
Abstract excerpt
OBJECTIVE: Kisspeptins (Kps), were first found to regulate the hypothalamopituitary-gonadal axis (HPG) axis in 2003, when two groups-demonstrated that mutations of GPR54 causes idiopathic hypogonadotropic hypogonadism (IHH) characterized by delayed puberty. Objective of this review is to highlight both animal and human discoveries in KISS1/GPR54 system in last decade and extrapolate the therapeutic potential in...
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