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Article

Focal Cortical Dysplasia: Gene Mutations, Cell Signaling, and Therapeutic Implications.

Annual review of pathology - 24 Jan 2017

Iffland Philip H, Crino Peter B

Abstract excerpt

Focal cortical dysplasias (FCDs) are malformations of cortical development (MCDs) that are highly associated with medication-resistant epilepsy and are the most common cause of neocortical epilepsy in children. FCDs are a heterogeneous group of developmental disorders caused by germline or somatic mutations that occur in genes regulating the PI3K/Akt/mTOR pathway-a key pathway in neuronal growth and migration....

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PMID: 28135561
DOI: 10.1146/annurev-pathol-052016-100138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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