Molecular mechanisms of canalization: Hsp90 and beyond.

Abstract excerpt

The Hsp90 chaperone machine facilitates the maturation of a diverse set of 'client' proteins. Many of these Hsp90 clients are essential nodes in signal transduction pathways and regulatory circuits,accounting for the important role Hsp90 plays in organismal development and responses to the environment. Recent findings suggest a broader impact of the chaperone on phenotype: fully functional Hsp90 canalizes...

Topics

• Animals
• Arabidopsis
• Drosophila melanogaster
• Epigenesis, Genetic
• Gene Expression Regulation
• Genotype
• HSP90 Heat-Shock Proteins
• Phenotype