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Article

Reduced CD146 expression promotes tumorigenesis and cancer stemness in colorectal cancer through activating Wnt/β-catenin signaling.

Oncotarget - 28 Jun 2016

Liu Dan, Du Lei, Chen Dong, Ye Zhongde, Duan Hongxia, Tu Tao, Feng Jing, Yang Yili, Chen Quan, Yan Xiyun

Abstract excerpt

Cancer stemness drives tumor progression and drug resistance, representing a challenge to cancer eradication. Compelling evidence indicates that cancer cells can reenter the stem cell state due to the reprogramming of self-renewal machinery. Here, we show that CD146 knockdown induces stem cell properties in colorectal cancer (CRC) cells through activating canonical Wnt signaling. shRNA-mediated CD146 knockdown in...

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Identifiers

PMID: 27302922
DOI: 10.18632/oncotarget.9930
PMCID: PMC5130037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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