Article
Estrogen accelerates heart regeneration by promoting inflammatory responses in zebrafish
2019-04-23
Abstract excerpt
Sexual differences are observed in the onset and prognosis of human cardiovascular diseases, but the underlying mechanisms are not clear. Here, we report that zebrafish heart regeneration is faster in females, can be accelerated by estrogen and suppressed by estrogen-antagonist tamoxifen. Injuries to the heart, but not other tissues, increased plasma estrogen level and expression of estrogen receptors, especially...
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Identifiers and source
- Literature Corpus work
- df0b8928-8ef9-5f49-b35f-1fd5c51cce04
- DOI
- 10.1101/616250