Article
Late developing cardiac lymphatic vasculature supports adult zebrafish heart function and regeneration.
eLife - 8 Nov 2019
Harrison Michael Rm, Feng Xidi, Mo Guqin, Aguayo Antonio, Villafuerte Jessi, Yoshida Tyler, Pearson Caroline A, Schulte-Merker Stefan, Lien Ching-Ling
Abstract excerpt
The cardiac lymphatic vascular system and its potentially critical functions in heart patients have been largely underappreciated, in part due to a lack of experimentally accessible systems. We here demonstrate that cardiac lymphatic vessels develop in young adult zebrafish, using coronary arteries to guide their expansion down the ventricle. Mechanistically, we show that in cxcr4a mutants with defective coronary...
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