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Multi-proteomic profiling of the varicella-zoster virus–host interface reveals host susceptibilities to severe infection

30 Jul 2025

Abstract excerpt

Varicella-zoster virus (VZV) infects most humans and causes chickenpox, shingles and central nervous system pathologies. The molecular basis for these phenotypes remains elusive. Here we conducted a multi-proteomic survey on 64 individual VZV proteins and infection-induced perturbations in a neuronal cell line, identifying 900 interactors and 3,618 regulated host proteins. Data integration suggested molecular...

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PMID: 40739040
DOI: 10.1038/s41564-025-02068-7

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