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Article

Expression of Ror2 mediates invasive phenotypes in renal cell carcinoma.

PloS one - 1 Jan 2014

Rasmussen Neal R, Debebe Zufan, Wright Tricia M, Brooks Samira A, Sendor Adam B, Brannon A Rose, Hakimi A Ari, Hsieh James J, Choueiri Toni K, Tamboli Pheroze, Maranchie Jodi K, Hinds Peter, Wallen Eric M, Simpson Catherine, Norris Jacqueline L, Janzen William P, Rathmell W Kimryn

Abstract excerpt

Ror2 is a Wnt ligand receptor that is overexpressed in a variety of tumors including clear cell renal cell carcinoma (ccRCC). Here we demonstrate that expression of wild type Ror2 results in increased tumorigenic properties in in vitro cell culture and in vivo xenograft models. In addition, Ror2 expression produced positive changes in both cell migration and invasion, which were dependent on matrix...

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Source

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Identifiers

PMID: 25542006
DOI: 10.1371/journal.pone.0116101
PMCID: PMC4277431

Genes

MMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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