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Article

ROR2 promotes the epithelial-mesenchymal transition by regulating MAPK/p38 signaling pathway in breast cancer.

Journal of cellular biochemistry - 1 Oct 2020

Xu Jin, Shi Junfeng, Tang Weiwei, Jiang Peng, Guo Muhong, Zhang Bin, Ma Ge

Abstract excerpt

Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a tyrosine-protein kinase receptor highly implicated in the growth plate and cartilage development, which may be involved in epithelial-mesenchymal transition (EMT) in breast cancer (BC) cells. Although ROR2 is known to promote the migration of BC cells, the detailed mechanism of this event is still not clear. Here, we found that ROR2 expression was...

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PMID: 32048761
DOI: 10.1002/jcb.29666

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