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Article

ROR1-STAT3 signaling contributes to ovarian cancer intra-tumor heterogeneity

3 Jul 2023

Abstract excerpt

Wnt pathway dysregulation through genetic and non-genetic alterations occurs in multiple cancers, including ovarian cancer (OC). The aberrant expression of the non-canonical Wnt signaling receptor ROR1 is thought to contribute to OC progression and drug resistance. However, the key molecular events mediated by ROR1 that are involved in OC tumorigenesis are not fully understood. Here, we show that ROR1 expression...

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PMID: 37400436
DOI: 10.1038/s41420-023-01527-6

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