Article

Quantitative Modeling of Insulin Signaling Reveals Mechanisms of Insulin Resistance in Obese Mice

2025-10-15

Abstract excerpt

Insulin resistance is a deficiency in insulin-mediated regulation of glucose metabolism and is considered a cause of multiple diseases such as diabetes and hypertension. The insulin signaling pathway’s contribution to insulin resistance remains incompletely understood. Insulin receptor (IR) mutations can cause insulin resistance; however, reduced IR expression in obesity may still permit sufficient signaling due t...

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Literature Corpus work: 2dd695a2-134e-5691-ba64-16d6cede72f8
DOI: 10.1101/2025.10.15.682504

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