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Article

Induction of psoriasis- and atopic dermatitis-like phenotypes in 3D skin equivalents with a fibroblast-derived matrix.

Scientific reports - 31 Jan 2023

Morgner Bianka, Tittelbach Jörg, Wiegand Cornelia

Abstract excerpt

Skin homeostasis is a complex regulated process relying on the crosstalk of keratinocytes, fibroblasts and immune cells. Imbalances of T-cell subsets and the cytokine environment can lead to inflammatory skin diseases such as psoriasis (Ps) and atopic dermatitis (AD). Modern tissue engineering provides several in vitro models mimicking Ps and AD phenotypes. However, these models are either limited in their...

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Contact Dermatitis and Allergies
Dermatitis, Atopic
Dermatology and Skin Diseases
Fibroblasts
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Psoriasis: Treatment and Pathogenesis

Reproducibility of Results

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Identifiers

PMID: 36720910
DOI: 10.1038/s41598-023-28822-7
PMCID: PMC9889787

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