Genetic innovation in coronaviruses driven by a viral nuclease

Abstract excerpt

Genetic variation in viruses is well known to arise from polymerase-driven nucleotide misincorporation. However, insertion and deletion (indel) mutations that occur at lower, largely unknown, frequencies can underly more dramatic phenotypic changes that emerge when advantageous. Using a human coronavirus (HCoV-OC43) construct that reports rare indel mutations, we show that non-structural protein-15 (NSP15), a nucl...

Topics

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• Chlorocebus aethiops
• Exoribonucleases
• Genetic Engineering
• Severe Acute Respiratory Syndrome
• Severe acute respiratory syndrome-related coronavirus
• Vero Cells
• Viral Nonstructural Proteins
• Virus Replication

Identifiers and source

Literature Corpus work

2dbbf808-0f3c-5a53-9c11-d8df63d0f129

DOI

10.64898/2026.08.15.744938