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Article

Diverse recombinant HIV-1 Envs fail to activate B cells expressing the germline B cell receptors of the broadly neutralizing anti-HIV-1 antibodies PG9 and 447-52D.

Journal of virology - 1 Mar 2014

McGuire Andrew T, Glenn Jolene A, Lippy Adriana, Stamatatos Leonidas

Abstract excerpt

UNLABELLED: Broadly neutralizing antibodies (bNAbs) against HIV-1 are generated during HIV-1-infection but have not yet been elicited by immunization with recombinant forms of the viral envelope glycoprotein (Env; the target of anti-HIV-1 neutralizing antibodies). A particular type of bNAb targets the CD4-binding site (CD4-BS) region of Env. These antibodies are derived from a limited number of VH/VL genes and...

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Share to env Gene Products, Human Immunodeficiency Virus

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Share to Hemagglutinin Glycoproteins, Influenza Virus

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Share to Receptors, Antigen, B-Cell

Source

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Identifiers

PMID: 24352455
DOI: 10.1128/JVI.03228-13
PMCID: PMC3958080

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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