Tuft cells act as regenerative stem cells in the human intestine

Abstract excerpt

<h4>ABSTRACT</h4> In mice, intestinal tuft cells have been described as a long-lived, post-mitotic cell type of which two distinct subsets have been identified, named tuft-1 and tuft-2 1 . By combining analysis of primary human intestinal resection material and intestinal organoids, we identify four distinct human tuft cell states, two of which overlap with their murine counterparts. We show that tuft cell devel...

Topics

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• Biochemical Analysis and Sensing Techniques
• Cancer Cells and Metastasis
• Congenital Diaphragmatic Hernia Studies
• Diet, Metabolism, and Disease
• Digestive system and related health
• Hippo pathway signaling and YAP/TAZ
• Pluripotent Stem Cells Research
• Renal and related cancers

Identifiers and source

Literature Corpus work

2d93e92f-8a25-5c56-b79f-cb275aa125cb

DOI

10.1101/2024.03.17.585165