Article

Statistical Coupling Analysis Predicts Correlated Motions in Dihydrofolate Reductase

2024-06-18

Abstract excerpt

The role of dynamics in enzymatic function is a highly debated topic. Dihydrofolate reductase (DHFR), due to its universality and the depth with which it has been studied, is a model system in this debate. Myriad previous works have identified networks of residues in positions near to and remote from the active site that are involved in dynamics and others that are important for catalysis. For example, specific mu...

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Literature Corpus work: 2d78b94d-47aa-518c-abea-38103ac76379
DOI: 10.1101/2024.06.18.599103

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