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Article

Allosteric regulatory control in dihydrofolate reductase is revealed by dynamic asymmetry.

Protein science : a publication of the Protein Society - 1 Aug 2023

Kazan I Can, Mills Jeremy H, Ozkan S Banu

Abstract excerpt

We investigated the relationship between mutations and dynamics in Escherichia coli dihydrofolate reductase (DHFR) using computational methods. Our study focused on the M20 and FG loops, which are known to be functionally important and affected by mutations distal to the loops. We used molecular dynamics simulations and developed position-specific metrics, including the dynamic flexibility index (DFI) and dynamic...

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Identifiers

PMID: 37313628
DOI: 10.1002/pro.4700
PMCID: PMC10357497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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