DHFR Mutants Modulate Their Synchronized Dynamics with the Substrate by Shifting Hydrogen Bond Occupancies.

Abstract excerpt

Antibiotic resistance is a global health problem in which mutations occurring in functional proteins render drugs ineffective. The working mechanisms of the arising mutants are seldom apparent; a methodology to decipher these mechanisms systematically would render devising therapies to control the arising mutational pathways possible. Here we utilize Cα-Cβ bond vector relaxations obtained from moderate length MD...

Topics

• Escherichia coli
• Hydrogen Bonding
• Kinetics
• Mutation
• Point Mutation
• Tetrahydrofolate Dehydrogenase
• Escherichia coli Proteins