Article

Synthesis of Cyclo-β-tripeptides and Their Biologicalin vitro Evaluation as Antiproliferatives against the Growth of Human Cancer Cell Lines

2001-10-17

Abstract excerpt

A number of cyclo-β-tripeptides and their linear precursors were subjected to primary biological evaluation for cancer-cell growth inhibition (one-dose, three-cell essay), and the five most active ones were then tested in the anti-tumor screen of the National Cancer Institute (Bethesda, USA) with 60 human cancer cell lines. Growth inhibition values GI50 in the one-digit micromolar, and in one case in the nanomolar...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2d4c2ed9-ddeb-521d-9c0b-2fb5f0f4203d
DOI: 10.1002/1522-2675(20011017)84:10<2924::aid-hlca2924>3.0.co;2-e

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 10 closest

Synthesis of Cyclo-β-tripeptides and Their Biologicalin vitro Evaluation as Antiproliferatives against the Growth of Human Cancer Cell LinesDOI 10.1002/1522-2675(20011017)84:10<2924::aid-hlca2924>3.0.co;2-eRead

Development of Mithramycin Analogues with Increased Selectivity toward ETS Transcription Factor Expressing CancersSemantic proximity Read

Antiproliferative and phenotype-transforming antitumor agents derived from cysteine.Semantic proximity Read

Design, Synthesis, and Biological Evaluation of Hybrid Molecules Containing α-Methylene-γ-Butyrolactones and α-Bromoacryloyl MoietiesSemantic proximity Read

Epothilone B and its Analogs - A New Family of Anticancer AgentsSemantic proximity Read

Antitumor Activity of Bruceantin: An Old Drug with New Promise<sup>,</sup>Semantic proximity Read

The biology and medicinal chemistry of epothilones.Semantic proximity Read

Cancer Targeting Radiopeptidomimetics in Molecular Nuclear MedicineSemantic proximity Read

Aegeline inspired synthesis of novel amino alcohol and thiazolidinedione hybrids with antiadipogenic activity in 3T3-L1 cellsSemantic proximity Read

Novel all-hydrocarbon stapled p110α[E545K] peptides as blockers of the oncogenic p110α[E545K]-IRS1 interaction.Semantic proximity Read

Hexapeptides from a mammalian inhibitory hormone activate and inactivate nematode reproductionSemantic proximity Read