Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antiproliferative and phenotype-transforming antitumor agents derived from cysteine.

Journal of medicinal chemistry - 3 Jun 2004

Glenn Matthew P, Kahnberg Pia, Boyle Glen M, Hansford Karl A, Hans Dhiraj, Martyn Adam C, Parsons Peter G, Fairlie David P

Abstract excerpt

Selective destruction of malignant tumor cells without damaging normal cells is an important goal for cancer chemotherapy in the 21st century. Differentiating agents that transform cancer cells to either a nonproliferating or normal phenotype could potentially be tissue-specific and avoid side effects of current drugs. However, most compounds that are presently known to differentiate cancer cells are histone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Benzylamines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carboxylic Acids

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to Cyclins

Share to Cysteine

Share to Drug Screening Assays, Antitumor

Share to Histones

Source

Identifiers

PMID: 15163181
DOI: 10.1021/jm030222i

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antiproliferative and phenotype-transforming antitumor agents derived from cysteine.PMID 15163181Read ↗

TACIMA-218: A Novel Pro-Oxidant Agent Exhibiting Selective Antitumoral Activity.Semantic proximity Read ↗

Expanding the Chemistry of Dihaloacetamides as Tunable Electrophiles for Reversible Covalent Targeting of Cysteines.Semantic proximity Read ↗

Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activitySemantic proximity Read ↗

Evolution of Nitrogen-Based Alkylating Anticancer AgentsSemantic proximity Read ↗

New Curcuphenol Analogues Possess Anti-Metastatic Biological ActivitySemantic proximity Read ↗

Design and synthesis of a C7-aryl piperlongumine derivative with potent antimicrotubule and mutant p53-reactivating properties.Semantic proximity Read ↗

Histone Deacetylase Inhibitors: Development of Suberoylanilide Hydroxamic Acid (SAHA) for the Treatment of CancersSemantic proximity Read ↗

A Concept on The Development of The DRDE Series of Compounds for Skin Diseases Using In-Silico ADME And Drug-Likeness AnalysisSemantic proximity Read ↗

The Development of MetAP-2 Inhibitors in Cancer TreatmentSemantic proximity Read ↗

Methyl sulfone induces loss of metastatic properties and reemergence of normal phenotypes in a metastatic cloudman S-91 (M3) murine melanoma cell line.Semantic proximity Read ↗

Potent Vinblastine C20′ Ureas Displaying Additionally Improved Activity Against a Vinblastine-Resistant Cancer Cell LineSemantic proximity Read ↗

Glutathione Transferase-M2-2 Secreted from Glioblastoma Cell Protects SH-SY5Y Cells from Aminochrome NeurotoxicitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.