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Epothilone B and its Analogs - A New Family of Anticancer Agents

1 Mar 2003

Abstract excerpt

Epothilones are naturally occurring 16-membered macrolides with the ability to promote tubulin polymerization in vitro and to stabilize preformed microtubules against Ca(2+)- or cold-induced depolymerization. In contrast to paclitaxel (Taxol((R))) epothilones are also active in vitro against multidrug-resistant cancer cell lines as well as cell lines whose paclitaxel-resistance is derived from specific...

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PMID: 12570848
DOI: 10.2174/1389557033405269

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Epothilone B and its Analogs - A New Family of Anticancer AgentsPMID 12570848Read ↗

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A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells.Semantic proximity Read ↗

Structural basis for drug resistance conferred by β-tubulin mutations: a molecular modeling study on native and mutated tubulin complexes with epothilone B.Semantic proximity Read ↗

Structural insight into the mechanism of epothilone A bound to beta-tubulin and its mutants at Arg282Gln and Thr274Ile.Semantic proximity Read ↗

Microtubules: A dynamic target in cancer therapySemantic proximity Read ↗

Tubulin-Interactive Natural Products as Anticancer AgentsSemantic proximity Read ↗

Much anticipated--the bioactive conformation of epothilone and its binding to tubulin.Semantic proximity Read ↗

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