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Article

Antitumor Activity of Bruceantin: An Old Drug with New Promise<sup>,</sup>

24 Dec 2003

Abstract excerpt

Bruceantin was first isolated from Brucea antidysenterica, a tree used in Ethiopia for the treatment of cancer, and activity was observed against B16 melanoma, colon 38, and L1210 and P388 leukemia in mice. Phase I and II clinical trials were then initiated, but no objective tumor regressions were observed and clinical development was terminated. Recently, the activity of bruceantin has been studied with a number...

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PMID: 14987068
DOI: 10.1021/np030304+

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