Dissecting the Genetic Causality Between Immune Cell Traits and ER-Negative Breast Cancer Outcomes

Abstract excerpt

<title>Abstract</title> <p>Estrogen receptor-negative (ER−) breast cancer is an aggressive subtype with limited therapeutic options. The immune system plays a critical role in tumor progression and patient prognosis, yet the causal relevance of specific immune traits remains unclear.We performed a bidirectional two-sample Mendelian randomization (MR) analysis to assess the causal relationships between 731 periphe...

Topics

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• Breast Neoplasms
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Immunophenotyping
• Mendelian Randomization Analysis
• Phenotype
• Polymorphism, Single Nucleotide
• Risk Factors

Identifiers and source

Literature Corpus work

2d459a88-edee-52fc-9fe3-4ebdb4e62117

DOI

10.21203/rs.3.rs-7166891/v1