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Article

A bidirectional Mendelian randomization analysis of the causal relationship between immune cells and high-grade squamous intraepithelial lesion.

Medicine - 21 Nov 2025

Wang Zhenyu, Yang Lu, Li Chunxiao, Jiang Ping, Wang Junjie

Abstract excerpt

High-grade squamous intraepithelial lesions (HSIL), critical precursors to cervical cancer, are associated with persistent human papillomavirus infection and immune dysregulation, yet the causal role of specific immune cell phenotypes remains unclear. To investigate bidirectional causal relationships, we performed a 2-sample Mendelian randomization (MR) analysis using European genome-wide association study data:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41305712
DOI: 10.1097/MD.0000000000045695
PMCID: PMC12643692

Genes

CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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