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Article

Fragile X mental retardation protein regulates protein expression and mRNA translation of the potassium channel Kv4.2.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Apr 2011

Gross Christina, Yao Xiaodi, Pong Dan L, Jeromin Andreas, Bassell Gary J

Abstract excerpt

A prominent characteristic of the inherited intellectual impairment disease fragile X syndrome (FXS) is neuronal hyperexcitability, resulting in a variety of symptoms, such as hyperactivity, increased sensitivity to sensory stimuli, and a high incidence of epileptic seizures. These symptoms account for a significant part of the disease pattern, but the underlying molecular mechanisms of neuronal hyperexcitability...

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Identifiers

PMID: 21490210
DOI: 10.1523/JNEUROSCI.6661-10.2011
PMCID: PMC3089949

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