Article

Skin RT-QuIC Assays are More Sensitive than CSF RT-QuIC in Prion Detection for Chinese Probable Sporadic Creutzfeldt-Jakob Disease

2020-10-19

Abstract excerpt

<title>Abstract</title> <p>BackgroundThe definite diagnosis of human sporadic Creutzfeldt-Jakob disease (sCJD) largely depends on postmortem neuropathology and PrP<sup>Sc </sup>detection in the brain. The development of prion RT-QuIC of cerebrospinal fluid (CSF) samples makes it possible for premortem diagnosis for sCJD. However the diagnostic potential of RT-QuIC of skin specimen for probable sCJD is not well re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2d043be4-5291-55f2-9a38-6fb20a5b5318
DOI: 10.21203/rs.3.rs-92251/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Skin RT-QuIC Assays are More Sensitive than CSF RT-QuIC in Prion Detection for Chinese Probable Sporadic Creutzfeldt-Jakob DiseaseDOI 10.21203/rs.3.rs-92251/v1Read

Comparative Analysis of The Characteristics of The Chinese gCJD Patients With E196A and E196K Mutation in PRNPSemantic proximity Read

Diagnostic and prognostic value of human prion detection in cerebrospinal fluid.Semantic proximity Read

Genetic Prion Disease: Insight from the Features and Experience of China National Surveillance for Creutzfeldt-Jakob Disease.Semantic proximity Read

The advances in the early and accurate diagnosis of Creutzfeldt-Jakob disease and other prion diseases: where are we today?Semantic proximity Read

Diagnostic Accuracy of Prion Disease Biomarkers in Iatrogenic Creutzfeldt-Jakob Disease.Semantic proximity Read

Creutzfeldt-Jakob Disease with Initial Typical Parkinsonism Precipitated by COVID-19? A Case ReportSemantic proximity Read

Cerebrospinal fluid and plasma biomarkers in individuals at risk for genetic prion diseaseSemantic proximity Read

Clinical and laboratory features of 14 young Chinese probable sCJD patients.Semantic proximity Read

Trajectories of neurodegeneration and seed amplification biomarkers prior to disease onset in individuals at risk of prion diseaseSemantic proximity Read

Profiles of 14-3-3 and Total Tau in CSF Samples of Chinese Patients of Different Genetic Prion DiseasesSemantic proximity Read

Cerebrospinal fluid and plasma biomarkers in individuals at risk for genetic prion diseaseSemantic proximity Read

Biomarker changes preceding symptom onset in genetic prion diseaseSemantic proximity Read