Article
Nanotechnology-enabled M2 macrophage polarization and ferroptosis inhibition for targeted inflammatory bowel disease treatment.
Journal of controlled release : official journal of the Controlled Release Society - 1 Mar 2024
Zhao Yuge, Yin Weimin, Yang Zichen, Sun Jiuyuan, Chang Jiao, Huang Li, Xue Liangyi, Zhang Xiaoyou, Zhi Hui, Chen Shiyu, Chen Nana, Li Yongyong
Abstract excerpt
Transforming macrophages into the anti-inflammatory M2 phenotype could markedly strengthen inflammatory bowel disease (IBD) treatment, which is considered as a promising strategy. However, the high ferroptosis sensitivity of M2 macrophages, which decreases their activity, is a major stumbling block to this strategy. Therefore, promoting M2 polarization while simultaneously inhibiting ferroptosis to tackle this...
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