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Article

A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site.

Blood - 6 Dec 2012

Nürnberg Sylvia T, Rendon Augusto, Smethurst Peter A, Paul Dirk S, Voss Katrin, Thon Jonathan N, Lloyd-Jones Heather, Sambrook Jennifer G, Tijssen Marloes R, Italiano Joseph E, Deloukas Panos, Gottgens Berthold, Soranzo Nicole, Ouwehand Willem H

Abstract excerpt

We recently identified 68 genomic loci where common sequence variants are associated with platelet count and volume. Platelets are formed in the bone marrow by megakaryocytes, which are derived from hematopoietic stem cells by a process mainly controlled by transcription factors. The homeobox transcription factor MEIS1 is uniquely transcribed in megakaryocytes and not in the other lineage-committed blood cells....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22972982
DOI: 10.1182/blood-2012-01-401893
PMCID: PMC3520622

Genes

MEIS1
DNM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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