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Thirty five novel nsSNPs may effect on <i>ADAMTS13</i> protein leading to Thrombotic thrombocytopenic purpura (TTP) using bioinformatics approach

2019-09-05

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Genetic polymorphisms in the ADAMTS13 gene are associated with thrombotic thrombocytopenic purpura or TTP, a life-threatening microangiopathic disorder. This study aims to predict the possible pathogenic SNPs of this gene and their impact on the protein structure and function using insilico methods. <h4>Methods</h4> SNPs retrieved from the NCBI database were analyzed usin...

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Literature Corpus work: da1aca8d-a2e7-595f-ade4-49ee0e2b1b0c
DOI: 10.1101/759787

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