Article
Validation of whole genome sequencing from dried blood spots.
BMC medical genomics - 20 Apr 2021
Agrawal Pooja, Katragadda Shanmukh, Hariharan Arun K, Raghavendrachar Vijayashree Gauribidanur, Agarwal Arunika, Dayalu Rashmi, Awasthy Disha, Sharma Sanjay C, Sivasamy Yasodha Kannan, Lakshmana P, Shanmugam Ashwini, Veeramachaneni Vamsi, Gupta Vaijayanti, Vani B P, Subaiya Lekha, Syamala T S, Hariharan Ramesh, Chandru Vijay, Bloom David E
Abstract excerpt
BACKGROUND: Dried blood spots (DBS) are a relatively inexpensive source of nucleic acids and are easy to collect, transport, and store in large-scale field surveys, especially in resource-limited settings. However, their performance in whole-genome sequencing (WGS) relative to that of venous blood DNA has not been analyzed for various downstream applications. METHODS: This study compares the WGS performance of...
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