Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

mTOR signalling: the molecular interface connecting metabolic stress, aging and cardiovascular diseases

29 Oct 2012

Abstract excerpt

The continuing increase in the prevalence of obesity and metabolic disorders such as type-II diabetes and an accelerating aging population globally will remain the major contributors to cardiovascular mortality and morbidity in the 21st century. It is well known that aging is highly associated with metabolic and cardiovascular diseases. Growing evidence also shows that obesity and metabolic diseases accelerate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to FOXO transcription factor regulation
Share to Genetics, Aging, and Longevity in Model Organisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23107260
DOI: 10.1111/j.1467-789x.2012.01038.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

mTOR signalling: the molecular interface connecting metabolic stress, aging and cardiovascular diseasesPMID 23107260Read ↗

mTOR and Aging: An Old Fashioned DressSemantic proximity Read ↗

Emerging Role of mTOR Signaling‐Related miRNAs in Cardiovascular DiseasesSemantic proximity Read ↗

The mTOR signaling pathway in cardiac agingSemantic proximity Read ↗

Unmasking the janus faces of autophagy in obesity‐associated insulin resistance and cardiac dysfunctionSemantic proximity Read ↗

The role of mTOR in age-related diseasesSemantic proximity Read ↗

mTOR as a central regulator of lifespan and agingSemantic proximity Read ↗

At the crossroads of longevity and metabolism: the metabolic syndrome and lifespan determinant pathwaysSemantic proximity Read ↗

Autophagy and cardiovascular agingSemantic proximity Read ↗

PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity.Semantic proximity Read ↗

mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and agingSemantic proximity Read ↗

Growth Factors, Nutrient Signaling, and Cardiovascular AgingSemantic proximity Read ↗

Longevity Pathways (mTOR, SIRT, Insulin/IGF-1) as Key Modulatory Targets on Aging and NeurodegenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.