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Accelerated replicative senescence of ataxia‐telangiectasia skin fibroblasts is retained at physiologic oxygen levels, with unique and common transcriptional patterns

30 May 2023

Abstract excerpt

The genetic disorder, ataxia-telangiectasia (A-T), is caused by loss of the homeostatic protein kinase, ATM, and combines genome instability, tissue degeneration, cancer predisposition, and premature aging. Primary fibroblasts from A-T patients exhibit premature senescence when grown at ambient oxygen concentration (21%). Here, we show that reducing oxygen concentration to a physiological level range (3%)...

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PMID: 37254625
DOI: 10.1111/acel.13869

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