Article
Skewed megakaryopoiesis in human induced pluripotent stem cell-derived haematopoietic progenitor cells harbouring calreticulin mutations.
British journal of haematology - 1 Jun 2018
Takei Hiraku, Edahiro Yoko, Mano Shuichi, Masubuchi Nami, Mizukami Yoshihisa, Imai Misa, Morishita Soji, Misawa Kyohei, Ochiai Tomonori, Tsuneda Satoshi, Endo Hiroshi, Nakamura Sou, Eto Koji, Ohsaka Akimichi, Araki Marito, Komatsu Norio
Abstract excerpt
Somatic mutations in the calreticulin (CALR) gene have been found in most patients with JAK2- and MPL-unmutated Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs). It has recently been shown that mutant CALR constitutively activates the thrombopoietin receptor MPL and, thus, plays a causal role in the development of MPNs. However, the roles of mutant CALR in human haematopoietic cell...
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