Article
The characteristics of CALR mutations in myeloproliferative neoplasms: a clinical experience from a tertiary care center in Qatar and a literature review.
Hematology (Amsterdam, Netherlands) - 1 Dec 2024
Najim Mostafa, Abu-Tineh Mohammad, Alshurafa Awni, Ibrahim Mohamed Izham Mohamed, Ansari Soubiya, Faraj Hazem, Alateeg Saif, Akiki Susanna Jane, Yassin Mohamed A
Abstract excerpt
BACKGROUND: Myeloproliferative neoplasms (MPNs) are hematological disorders characterized by abnormal production of myeloid cells due to genetic mutations. Since 2013, researchers have identified somatic mutations in the Calreticulin (CALR) gene, primarily insertions or deletions, in two Philadelphia chromosome-negative MPNs; essential thrombocytosis (ET) and primary myelofibrosis (PMF), and occasionally in...
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