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Article

Myeloproliferative Neoplasms With Calreticulin Mutations Exhibit Distinctive Morphologic Features.

American journal of clinical pathology - 1 Mar 2016

Loghavi Sanam, Bueso-Ramos Carlos E, Kanagal-Shamanna Rashmi, Ok C Young, Salim Alaa A, Routbort Mark J, Mehrotra Meenakshi, Verstovsek Srdan, Medeiros L Jeffrey, Luthra Rajyalakshmi, Patel Keyur P

Abstract excerpt

OBJECTIVES: Calreticulin (CALR) mutations are present in 50% to 85% of JAK2/MPL wild-type (wt) myeloproliferative neoplasms (MPNs). The histopathologic features of CALR-mutated MPNs are unknown. METHODS: We identified 71 patients with essential thrombocythemia (ET), primary myelofibrosis (PMF), and post-essential thrombocythemia myelofibrosis (post-ET MF) with available CALR status. CALR was assessed using...

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Source

Identifiers

PMID: 27124925
DOI: 10.1093/ajcp/aqw005

Genes

CALR
JAK2
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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