Article

TARGETED INHIBITION IN PEDIATRIC MET and ALK ALTERED PEDIATRIC HIGH GRADE GLIOMAS: OBJECTIVE RESPONSES FOLLOWED BY TREATMENT RESISTANCE

2025-07-12

Abstract excerpt

<h4>Purpose: </h4> : Pediatric-type Diffuse High Grade Gliomas (pHGG) tend to have a dismal prognosis. Some of these gliomas feature alterations in genes such as ROS1, ALK, MET, and NTRK1-3. Despite advances in categorization and development of targeted agents, the therapeutic application of these agents in pHGG is still unclear. The aim of this study is to report the outcome of two patients with pHGG who received...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2cd1ec32-4c8b-5067-8b99-23089a64043f
DOI: 10.22541/au.175231445.55763704/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TARGETED INHIBITION IN PEDIATRIC MET and ALK ALTERED PEDIATRIC HIGH GRADE GLIOMAS: OBJECTIVE RESPONSES FOLLOWED BY TREATMENT RESISTANCEDOI 10.22541/au.175231445.55763704/v1Read

Therapeutic Targets in Diffuse Midline Gliomas—An Emerging LandscapeSemantic proximity Read

Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable OutcomesSemantic proximity Read

Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas.Semantic proximity Read

Emerging paradigm: Molecularly targeted therapy with Dabrafenib and Trametinib in recurring pediatric gliomas with BRAF mutations: A narrative review.Semantic proximity Read

New strategies in pediatric gliomas: molecular advances in pediatric low-grade gliomas as a model.Semantic proximity Read

Comprehensive molecular characterization of pediatric treatment-induced high-grade glioma: A distinct entity despite disparate etiologies with defining molecular characteristics and potential therapeutic targetsSemantic proximity Read

Molecular-guided therapy for the treatment of patients with relapsed and refractory childhood cancers: a Beat Childhood Cancer Research Consortium trialSemantic proximity Read

From Molecular Alterations to the Targeted Therapy: Treatment of Thalamic Glioma in Pediatric Patients.Semantic proximity Read

Pediatric low-grade glioma in the era of molecular diagnostics.Semantic proximity Read

Clinical management and genomic profiling of pediatric low-grade gliomas in Saudi Arabia.Semantic proximity Read

The impact of molecularly matched treatment and tumor mutational burden on pediatric brain tumor patient outcomesSemantic proximity Read

Molecular-Targeted Therapy for Childhood Brain Tumors: A Moving TargetSemantic proximity Read