Article

Discovery of hALPL Agonists for Osteogenesis from A Selenium-containing DNA-encoded Natural Product Library

2025-09-11

Abstract excerpt

<title>Abstract</title> <p>Tissue-nonspecific alkaline phosphatase (hALPL) deficiency or dysfunction is a key driver of bone developmental abnormalities. However, no small-molecule agonists are available for the therapeutic target hALPL—particularly its pathogenic mutants. We bridge this gap by developing an antibody maturation-inspired chemical maturation strategy that integrates DNA-encoded library (DEL) select...

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Literature Corpus work: 2cbfda26-8228-5804-acad-d07f853c02a1
DOI: 10.21203/rs.3.rs-7459537/v1

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