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Article

Nuclear receptor DHR4 controls the timing of steroid hormone pulses during Drosophila development.

PLoS biology - 1 Sept 2011

Ou Qiuxiang, Magico Adam, King-Jones Kirst

Abstract excerpt

In insects, precisely timed periodic pulses of the molting hormone ecdysone control major developmental transitions such as molts and metamorphosis. The synthesis and release of ecdysone, a steroid hormone, is itself controlled by PTTH (prothoracicotopic hormone). PTTH transcript levels oscillate with an 8 h rhythm, but its significance regarding the timing of ecdysone pulses is unclear. PTTH acts on its target...

Topics

Animals
Animals, Genetically Modified
Cell Nucleus
Cytochrome P-450 Enzyme System
Drosophila Proteins
Drosophila melanogaster
Ecdysone
Endocrine Glands
Gene Expression Profiling
Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Knockdown Techniques

Insect Hormones

Larva

Mitogen-Activated Protein Kinases

Molting

Mutation

Oligonucleotide Array Sequence Analysis

Periodicity

Source

Open in PubMed Open full text

Identifiers

PMID: 21980261
DOI: 10.1371/journal.pbio.1001160
PMCID: PMC3181225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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