Article
SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development.
Molecular cell - 1 Aug 1999
Tsai C C, Kao H Y, Yao T P, McKeown M, Evans R M
Abstract excerpt
The Drosophila ecdysone receptor (EcR)/ultraspiracle (USP) heterodimer is a key regulator in molting and metamorphoric processes, activating and repressing transcription in a sequence-specific manner. Here, we report the isolation of an EcR-interacting protein, SMRTER, which is structurally divergent but functionally similar to the vertebrate nuclear corepressors SMRT and N-CoR. SMRTER mediates repression by...
Topics
- Amino Acid Sequence
- Animals
- Biological Evolution
- Cell Line
- Chromosome Mapping
- Chromosomes
- Co-Repressor Proteins
- DNA-Binding Proteins
- Drosophila Proteins
- Drosophila melanogaster
- Female
- Genetic Variation
- Male
- Molecular Sequence Data