Article

Defective thyroid hormone transport to the brain leads to astroglial alterations

2024-01-31

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Allan-Herndon-Dudley syndrome (AHDS) is a rare X-linked disorder that causes severe neurological damage, for which there is no effective treatment. AHDS is due to inactivating mutations in the thyroid hormone transporter MCT8 that impair the entry of thyroid hormones into the brain, resulting in cerebral hypothyroidism. However, the pathophysiology of AHDS is st...

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Literature Corpus work: 2ca1fdb3-e695-5cc5-a7fe-ecabcad9d71c
DOI: 10.21203/rs.3.rs-3825537/v1

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