Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome.

doi:10.1523/JNEUROSCI.6055-08.2009

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Article

Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 29 Jul 2009

Wirth Eva K, Roth Stephan, Blechschmidt Cristiane, Hölter Sabine M, Becker Lore, Racz Ildiko, Zimmer Andreas, Klopstock Thomas, Gailus-Durner Valerie, Fuchs Helmut, Wurst Wolfgang, Naumann Thomas, Bräuer Anja, de Angelis Martin Hrabé, Köhrle Josef, Grüters Annette, Schweizer Ulrich

Abstract excerpt

Thyroid hormone transport into cells requires plasma membrane transport proteins. Mutations in one of these, monocarboxylate transporter 8 (MCT8), have been identified as underlying cause for the Allan-Herndon-Dudley syndrome, an X-linked mental retardation in which the patients also present with abnormally high 3',3,5-triiodothyronine (T(3)) plasma levels. Mice deficient in Mct8 replicate the thyroid hormone...

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PMID: 19641107
DOI: 10.1523/JNEUROSCI.6055-08.2009
PMCID: PMC6666526

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