Article

Spatiotemporal expression of thyroid hormone transporter MCT8 and <i>THRA</i> mRNA in human cerebral organoids recapitulating first trimester cortex development

2023-11-17

Abstract excerpt

Thyroid hormones (TH) play critical roles during nervous system development and patients carrying coding variants of MCT8 (Monocarboxylate transporter 8) or THRA (Thyroid hormone receptor alpha) present a spectrum of neurological phenotypes resulting from perturbed local TH action during early brain development. Recently, human cerebral organoids (hCOs) emerged as powerful three-dimensional in vitro tools for dis...

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Literature Corpus work: fef36ad7-cabc-5dc6-9ffd-093c432544f8
DOI: 10.1101/2023.11.16.567497

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