Article

Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast cross-talk and induces the development of oral submucosal fibrosis

2023-10-27

Abstract excerpt

<title>Abstract</title> <p>Oral submucous fibrosis (OSF) is a chronic and inflammatory mucosal disease caused by betel quid chewing, which is an oral potential malignant disorder. The abnormal differentiation of fibroblasts leading to collagen metabolism disorder is the core process of OSF development. As the first line of defense against the external environment, epithelium can convert external signals into path...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 583bc4ae-cdeb-5b9d-a9d5-6d80057c1e2f
DOI: 10.21203/rs.3.rs-3434853/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast cross-talk and induces the development of oral submucosal fibrosisDOI 10.21203/rs.3.rs-3434853/v1Read

Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosisSemantic proximity Read

miR-203 inhibits arecoline-induced epithelial-mesenchymal transition by regulating secreted frizzled-related protein 4 and transmembrane-4 L six family member 1 in oral submucous fibrosisSemantic proximity Read

Aberrant SSEA-4 upregulation mediates myofibroblast activity to promote pre-cancerous oral submucous fibrosisSemantic proximity Read

Role of the arecoline/YAP1/BMP4 pathway in promoting endothelial‐mesenchymal transition in oral submucous fibrosisSemantic proximity Read

Elevation of Twist expression by arecoline contributes to the pathogenesis of oral submucous fibrosisSemantic proximity Read

Emerging functions and clinical applications of exosomes in human oral diseasesSemantic proximity Read

Exosome‐derived long non‐coding RNA ADAMTS9‐AS2 suppresses progression of oral submucous fibrosis via AKT signalling pathwaySemantic proximity Read

Comparative functional and molecular analysis of oral submucous fibrosis to oral squamous cell carcinoma: A pathway-based dynamic network analysisSemantic proximity Read

Cancer Exosomes Trigger Fibroblast to Myofibroblast DifferentiationSemantic proximity Read

The diverse role of oral fibroblasts in normal and diseaseSemantic proximity Read

A critical role of AREG for bleomycin-induced skin fibrosisSemantic proximity Read

Prostaglandin E₂ Reverses Myofibroblast Differentiation in Eosinophilic EsophagitisSemantic proximity Read