Article
Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species.
Journal of evolutionary biology - 1 Feb 2023
Verbiest Max, Maksimov Mikhail, Jin Ye, Anisimova Maria, Gymrek Melissa, Bilgin Sonay Tugce
Abstract excerpt
Short tandem repeats (STRs) are units of 1-6 bp that repeat in a tandem fashion in DNA. Along with single nucleotide polymorphisms and large structural variations, they are among the major genomic variants underlying genetic, and likely phenotypic, divergence. STRs experience mutation rates that are orders of magnitude higher than other well-studied genotypic variants. Frequent copy number changes result in a...
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