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Higher Purity of Phosphatidylserine Improves Human Cortical Neuron Function by Modulating SIRT1-PGC-1α Pathways

2025-12-25

Abstract excerpt

While phosphatidylserine (PS) is recognized for its neuroprotective properties, the effects of PS purity on human cortical neurons remains unexplored. This study investigates three different PS purities (15 µM of 50%, 70%, and 80%) on neuronal health using human embryonic stem cell-derived cortical neurons. Our findings reveal that higher PS purity enhances the expression of key regulatory proteins SIRT1 and PGC-1...

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Literature Corpus work
2c7d7004-82e4-5108-b5c0-1da40281cb0b
DOI
10.20944/preprints202512.2349.v1
Open publication

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