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Article

Mitochondrial biogenesis and neural differentiation of human iPSC is modulated by idebenone in a developmental stage-dependent manner.

Biogerontology - 1 Aug 2017

Augustyniak J, Lenart J, Zychowicz M, Stepien P P, Buzanska L

Abstract excerpt

Idebenone, the synthetic analog of coenzyme Q10 can improve electron transport in mitochondria. Therefore, it is used in the treatment of Alzheimer's disease and other cognitive impairments. However, the mechanism of its action on neurodevelopment is still to be elucidated. Here we demonstrate that the cellular response of human induced pluripotent stem cells (hiPSC) to idebenone depends on the stage of neural...

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Identifiers

PMID: 28643190
DOI: 10.1007/s10522-017-9718-4
PMCID: PMC5514205

Genes

MAP2
GFAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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