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Extracellular Vesicles from hiPSC-derived NSCs Protect Human Neurons against Aβ-42 Oligomers Induced Neurodegeneration, Mitochondrial Dysfunction and Tau Phosphorylation

2024-07-16

Abstract excerpt

<h4>Background</h4> Alzheimer’s disease (AD) is characterized by the accumulation of amyloid beta-42 (Aβ-42) in the brain, causing various adverse effects. Thus, therapies that reduce Aβ-42 toxicity in AD are of great interest. One promising approach is to use extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells (hiPSC-NSC-EVs) because they carry multiple therapeutic miRNAs an...

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Literature Corpus work: b71e4211-ca3c-514b-a27d-cb5c8d40ff48
DOI: 10.1101/2024.07.11.603159

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