Role of <i>Filia</i> , a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis

Abstract excerpt

During oogenesis, mammalian eggs accumulate proteins required for early embryogenesis. Although limited data suggest a vital role of these maternal factors in chromatin reprogramming and embryonic genome activation, the full range of their functions in preimplantation development remains largely unknown. Here we report a role for maternal proteins in maintaining chromosome stability and euploidy in early-cleavage...

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