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High proportion of multiple copies of <i>Plasmodium falciparum Plasmepsin-2</i> gene in African isolates: Is piperaquine resistance emerging in Africa?

2018-07-03

Abstract excerpt

Emergence of Plasmodium falciparum resistance to antimalarial drugs is currently the primary rationale supporting the development of new and well-tolerated drugs. In 2014-2015, a phase 2b clinical study was conducted to evaluate the efficacy of a single oral dose of Artefenomel (OZ439)-piperaquine (PPQ) in Asian and African patients presenting with uncomplicated falciparum malaria. Blood samples collected before...

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Literature Corpus work
2c68359e-6b62-5398-9a27-00f85db76ca0
DOI
10.1101/361204
Open publication

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High proportion of multiple copies of <i>Plasmodium falciparum Plasmepsin-2</i> gene in African isolates: Is piperaquine resistance emerging in Africa?DOI 10.1101/361204
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