Incidence of kelch13 and Pfmdr1 gene mutations associated with antimalarial drug resistance in Plasmodium falciparum isolates from Ethiopia: a systematic review and meta-analysis.

Abstract excerpt

BACKGROUND: The increasing prevalence of drug-resistant Plasmodium parasites, driven by factors including genetic mutations, intensifies the challenge of malaria eradication. This meta-analysis focused on the genetic component of resistance, specifically evaluating mutations in the kelch13 (R622I, P441L and A675V) and Pfmdr1 (Y184F and D1246Y) genes within Ethiopian Plasmodium falciparum strains. METHODS: A...

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